Immunomodulatory Treatment for Infertile Men with Antisperm Antibodies.pdf - created by pdfMachine from Broadgun Software, http://pdfmachine.com, a great PDF writer utility!
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چکیده
One of the important categories of subfertility or infertility in humans may be immunological diseases mediated by antisperm antibodies (ASA). Blood sera from 35 infertile men of different age with ASA positive ELISA test were examined for the serum level of ASA before and after treatments with 1,25-dihydroxy-Vitamin-D3 and Dexamethasone. We treated 18 infertile men with VitaminD3/Dexamethasone during 30 days, 9 infertile men with Dexamethasone only during 30 days and 8 infertile men received no treatment. All the patients showed poor parameters of spermogram and high level of ASA serum concentration (>75 U/ml). Serum concentration of ASA in non-treated group (313 U/ml), Dexamethasone only treated group (288) and Vitamin-D3/Dexamethasone treated group (124 U/ml) were significantly different. Serum level of ASA in Vitamin-D3/Dexamethasone treated group was significantly lower compared to the level before the treatment (P<0.01). These findings could be explained by immunosuppressive and immunomodulatory effects of Dexamethasone and Vitamin D3 treatment.
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